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If you do - remove the IUSR_xxxxx account from the guests group on the local machine and restart IIS (iisreset). I was receiving Event IDs 13042, 12002, 12012, 12032, 12022, 12042, and 12052.WSUS was installed on a machine that also had Exchange installed and was using the default website (on port 80) for web mail.Make sure the IP address restriction exceptions for the virtual directory are configured for the server's actual IP.Go to the Selfupdate virtual directory Properties, click "Edit" under IP address and domain name restrictions.After 10 minutes, the error was corrected automatically and the event log said all websites were working now. Do the following to fix the problem: Open IIS Manager, right click the Default Web Site, and look at the properties tab.
Once we changed the port on the default website and started it, this problem disappeared.WSUS seems not to work when the IIS web is not bound to "all addresses".I was getting a bunch of errors: 12002, 12032, 12022, 12042, 12052 for WSUS 3.0 SP1.Apparently usecustomwebsite does some changes other than the registry which seems to have fixed my problem.
In my case we were using RPCo HTTP with an SSL Cert and the Default Website was configured to Require Secure channel (SSL) and Require 128-bit encryption under Directory security.
I fixed this by enabling the iusr_serverx account in AD that was being used for anonymous authentication by this is IIS.